Nov 3rd 2025
Too Tired to Exercise? It May Be Those Statins You're Taking
. . . fatigue and exercise intolerance found common with statinsAlthough most labels on statin drugs list fatigue as a possible side effect, they give the impression that it’s rare. However, a new double-blind, placebo-controlled study published in the Archives of Internal Medicine has found that both decreased energy and fatigue with exertion are significantly greater in those who take statins. The strength of this effect correlated with the degree of cholesterol reduction and was greater in women than in men. The effects also correlated with reduced physical activity and exercise intolerance.More than 1,000 adults (men over the age of twenty, and women past menopause) were given either 20 mg Zocor or 40 mg Pravachol daily or a placebo for 6 months. People with heart disease or diabetes were excluded, but all subjects had LDL levels from 115 to 190 mg/dL. They were asked to rate their “energy level” and “fatigue with exertion” on a 5-point scale at the beginning and at the end of the…
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